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・ 120P/Mueller
・ 120s
・ 120s BC
・ 120th (City of Hamilton) Battalion, CEF
・ 120th Airlift Wing
・ 120th Brigade
・ 120th Brigade (United Kingdom)
・ 120th Delaware General Assembly
・ 12-channel carrier system
・ 12-cm Kanone M 80
・ 12-Crown-4
・ 12-hour clock
・ 12-hour run
・ 12-hydroxydihydrochelirubine 12-O-methyltransferase
・ 12-Hydroxyeicosatetraenoic acid
12-Hydroxyheptadecatrienoic acid
・ 12-inch coast defense mortar
・ 12-inch gun M1895
・ 12-inch mortar
・ 12-inch single
・ 12-metre class
・ 12-O-Tetradecanoylphorbol-13-acetate
・ 12-oxophytodienoate reductase
・ 12-pounder gun
・ 12-pounder long gun
・ 12-String Blues
・ 12-volt battery
・ 12-volt outlet
・ 12.10
・ 12.17×42mm RF


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12-Hydroxyheptadecatrienoic acid : ウィキペディア英語版
12-Hydroxyheptadecatrienoic acid

12-Hydroxyheptadecatrenoic acid (12-HHT, 12-hydroxy-heptadecatrienoic acid, 12(S)-HHTrE) is a 17 carbon metabolite of the 20 carbon polyunsaturated fatty acid, arachidonic acid. It was first detected and structurally defined by P. Wlodawer, B. Samuelsson, and M. Hamberg as a product of arachidonic acid metabolism made by microsomes (i.e. endoplasmic reticulum) isolated from sheep seminal vesicle glands and by intact human platelets.〔J. Biol. Chem. 248:5673; 1973〕〔Proc. Natl. Acad. Sci. USA 71:3400; 1974〕 12-HHT is less ambiguously termed 12-(''S'')-hydroxy-5''Z'',8''E'',10''E''-heptadecatrienoic acid to indicate the ''S'' stereoisomerism of its 12-hydroxyl residue and the ''Z'', ''E'', and ''E'' cis-trans isomerism of its three double bonds. The metabolite was for many years thought to be merely a biologically inactive byproduct of prostaglandin synthesis. More recent studies, however, have attached potentially important activity to it.
== Production ==


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